The mechanism of action is associated with selective blockade of reverse neuronal serotonin (5HT receptors) in the synapses of neurons in the central nervous system, it has little effect on the reuptake of dopamine. Profluzak is a weak antagonist of cholinergic, adrenergic alpha 1 and alpha 2-receptor, the receptors. Unlike other antidepressants hardly causes reduction in functional activity Beta postsynaptic adrenoceptors. It improves mood, reduces the feeling of fear and stress, obsessive-compulsive disorders, eliminates dysphoria, causes a decrease in appetite. It does not have a sedative effect. When receiving a secondary therapeutic doses has no effect on the cardiovascular and other systems.
Persistent clinical effect develops omnadren 250 cycle after 2 weeks. Regular ingestion and lasts for a few weeks after its cancellation.
Good (95%) absorbed from the gastrointestinal tract. Food does not affect the extent of absorption, but slows down its speed.
Maximum plasma concentrations determined 6-8 hours after administration. Communication with plasma proteins – 90%. Bioavailability – 60%. It penetrates into the fabric, including the BBB. It is metabolized in the liver by dimethylation to the active metabolite norfluoxetine, and others. Unidentified metabolites. It is shown mainly kidneys, 12% – via the intestine. The half-life of fluoxetine is about 2-3 days, norfluoxetine – 7-9 days. Patients with liver failure half-life is lengthened.Pierce (25% of plasma concentrations) in breast milk.
- Depression different genesis;
- obsessive-compulsive disorders;
- bulimic neurosis
When depression of various origins, obsessive-compulsive states, the initial dose – 20 mg 1 time / day. in the first half of the day, without food. If necessary, the weekly dose is increased to 40-60 mg / day, divided into 2-3 doses. The maximum daily dose – 80 mg, the multiplicity of reception – 2-3 times / day. The course of treatment – 3-4 weeks. When bulimic neurosis – 20 mg 3 times / day.
At the beginning of treatment or when increasing the dose temporarily may include headache, nervousness, insomnia, increased anxiety, fatigue, incontinence or urinary retention, decreased libido, dysmenorrhea, vaginitis, delayed ejaculation, loss of appetite, taste disturbances, dry mouth, nausea , vomiting, diarrhea, weight loss.
Rare: hyponatremia, omnadren 250 cycle allergic reactions (skin rash, angioedema, urticaria, pruritus, burning sensation), orthostatic hypotension, tachycardia, disturbance of the visual acuity, pain in muscles and joints.
- Hypersensitivity to the drug;
- atony of the bladder;
- severely impaired renal function;
- angle-closure glaucoma;
- prostate adenoma;
- convulsions of various origins;
- co-administration of MAO inhibitors;
- lactation (breastfeeding);
With care, under the strict supervision of a doctor prescribed drug for diseases of the cardiovascular system, abuse during treatment of liver and kidney function in patients with diabetes may develop hypoglycemia Profluzakom and after its cancellation – hyperglycemia, which requires correction dosing regimen hypoglycemic drugs.
In patients with epilepsy (including history) when applying omnadren 250 cycle there is a possibility of seizures. Period between the cancellation and start taking inhibitors must be at least 2 weeks., And between the cancellation and starting therapy MAO inhibitors for at least 5 weeks.
During the administration of the drug is necessary to eliminate the use of alcohol, and to refrain from potentially hazardous activities that require increased attention and psychomotor speed reactions.
Incompatible with MAO inhibitors, furazolidonom, procarbazine, selegelinom, tryptophan – can be “serotonin syndrome” (hyperthermia, muscle rigidity, myoclonus, agitation, seizures, dysarthria, hypertensive crisis, chills, tremors, nausea, vomiting, diarrhea). At simultaneous application with the drugs, have a depressing effect on the central nervous system (including ethanol) reinforces their effect. It enhances the effect of tricyclic and tetracyclic antidepressants, trazodone, carbamazepine, diazepam, metoprolol, terfenadine, phenytoin (phenytoin), anticoagulants and hypoglycemic drugs. Simultaneous omnadren 250 cycle treatment with lithium therapy leads to an increase in the plasma concentration of lithium.