Prothionamide rapidly absorbed in the gastrointestinal tract, creating a maximum concentration of drug in plasma within 2-3 hours after ingestion. It penetrates into healthy and pathologically altered tissue (tubercular lesions and cavities in the lungs, serous and purulent pleural fluid, cerebrospinal fluid in meningitis). The body is partially converted to the sulfoxide with a tuberculostatic activity. Partially allocated unchanged omnadren 250 results (up to 15-20% of the dose), kidneys and intestines.
Indications for use :
Prothionamide used to treat all forms of TB (as pulmonary and extrapulmonary), including the resistance of the pathogen to other anti-TB drugs (I series) or intolerance.
Prothionamide can not be used when an individual hypersensitivity to the drug during pregnancy and lactation, in children up to 3 years, lactose intolerance, lactase deficiency, glucose-galactose malabsorption (lactose as part of the drug), acute gastritis, gastric ulcer and 12 duodenal ulcer, erosive and ulcerative colitis, acute hepatitis, liver cirrhosis, chronic alcoholism.
diabetes mellitus, severe liver failure.
Dosage and administration :
Is drug inside after eating. Adults appoint 0.25 g three times a day; with good endurance – 0.5 g 2 times a day. In patients older than 60 years and with a body weight less than 50 kg the daily dose should not exceed 0.75 g (often prescribed to 0.25 g 2 times a day). The maximum daily dose for adults – 1 Year Duration of treatment – 8-9 months. Children older than 3 years – the rate of 10-20 mg / kg of body weight per day.
Side effects : From the digestive omnadren 250 results system: nausea, vomiting, diarrhea, dryness of the oral mucosa, hypersalivation, “metallic” taste in the mouth, increased activity of “liver” transaminases, abnormal liver function until the development of hepatitis. Nervous system: insomnia , agitation, depression, anxiety, impaired concentration, dizziness, drowsiness, headache, fatigue, paresthesia, mental disorders, peripheral neuropathy, optic neuritis. cardio-vascular system: tachycardia, orthostatic hypotension. From the endocrine: hypoglycemia in diabetic patients, gynecomastia, dysmenorrhea, hypothyroidism, reduced potency. Allergic reactions: skin rash. Other: pellagropodobnye reactions weakness.
The most frequently observed dyspeptic symptoms, which stoped fractional appointment of the drug and taking it after a meal, as well as the appointment of antiemetics.
Interaction with other drugs :
Combined therapy of tuberculosis should be taken into account additive hepatotoxic effects of certain drugs. This particularly relates to the combination protionamide with isoniazid, rifampicin and pyrazinamide. An additive effect on the central nervous system observed in the combined use of isoniazid and cycloserine. Compatible with isoniazid, pyrazinamide, cycloserine and other anti-TB drugs.Isoniazid increases the concentration protionamide plasma.
Simultaneous reception of alcohol leads to depression of the central nervous system. In certain cases, when receiving protionamide need to reduce the dose of insulin or oral antidiabetic drugs used for oral administration.
Special instructions :
. Joint use protionamide and alcohol should be avoided because of the danger of a depression of the central nervous system (associated with increased toxic effect of alcohol)
course of treatment is recommended to begin after determining the sensitivity of the bacteria and to determine the dose based on the individual sensitivity and tolerance.
The combined use of protionamide omnadren 250 results with isoniazid and cycloserine should pay attention to the possibility of mental disorders.
Because the drug is used continuously in combination with other anti-TB drugs, and monthly monitoring of liver function. In patients with diabetes need to control blood glucose levels at least once a month.
At the first signs pellagropodobnyh side effects you need to stop taking the drug.
In the period of treatment must be careful when driving vehicles and mechanisms, involvement in potentially hazardous activities, require high concentration and psychomotor speed reactions.