Protamine sulfate is a specific antagonist of heparin. 1 mg of protamine sulfate neutralizes 80 – 120 IU heparin in the blood. Complexing cationic groups due to the abundance of (due arignina) that bind heparin with anionic centers. Effect of the drug after intravenous administration occurs immediately and lasts for 2 hours.After intravenous administration of protamine-complexed heparin, omnadren vs sustanon which can break down to release the heparin. In case of overdose can reduce blood clotting, since protamine sulfate itself exhibits anticoagulant activity.
- Bleeding due to an overdose of heparin;
- before surgery in patients who are taking heparin for therapeutic purposes;
- after operations on the heart and blood vessels with extracorporeal circulation;
- Increased chuvstvitelnost to the drug;
- idiopathic or congenital gipergeparinemii (in such cases, medication is not effective, and may increase bleeding);
- severe hypotension;
- adrenocortical insufficiency;
- patients receiving insulin containing protamine sulfate and other drugs containing protamine sulfate;
- Allergic reactions to omnadren vs sustanon fish history.
Experience in medical use in children is limited.
Use during pregnancy and lactation
is possible if the expected effect of therapy outweighs the potential risk to the fetus.
Dosing and Administration
The solution of protamine sulphate injected slowly intravenously or drip. Speed must not introduce prevyshat’5 mg per minute (for example 50 mg dose administered over 10 minutes) as well as faster administration can cause anaphylactoid reactions. Dose depends on the route of administration of heparin. The calculated dose is dissolved with 300-500 ml of 0.9% sodium chloride solution. Do not enter more than 150 mg of protamine sulfate for 1 hour.
Side effect On the part of the cardiovascular system: decrease in blood pressure, bradycardia. From the digestive system: nausea, vomiting. Immune system: skin rash, itching, development of anaphylactoid reactions. Other: sensation of heat, flushing of the skin, a feeling of lack of air ( when excessively rapid introduction).
may be accompanied by bleeding, as omnadren vs sustanon has its own anticoagulant activity. Treatment – symptomatic. Interaction with other medicinal products incompatible with penicillins and cephalosporins. It is the antagonist of low molecular weight heparins. It may increase the intensity and duration of action of non-depolarizing muscle relaxants.
Introduction is performed under the control of blood clotting. Prior to administration, ensure the adequacy of the patient’s blood volume (hypovolemia increases the risk of collapse).
The solution for intravenous administration of 10 mg / ml to 2 ml or 5 ml ampoules. 5 vials are placed in blisters made of PVC film.
1 or 2 blisters with instruction on use and lancet ampoule or ampoule knife placed in a pile of cardboard.
5, or 10 vials with the instructions for use and lancet ampoule or ampoule knife placed in a box made of corrugated cardboard with a liner.
When using vials with a point or ring fracture scarifier knife or ampoule do not invest.