The specific dose when administered to which it was possible to talk about an overdose of insulin has not been established, however, in cases where omnadren the patient is administered the dose is too high, surpassing them. needs may develop state of hypoglycemia of varying severity:
- Mild hypoglycemia patient can remove himself, taking into sugar or rich, carbohydrate foods. Therefore, patients with diabetes should always carry sugar, sweets, biscuits or sugary fruit juice.
- In severe cases, loss of consciousness in a patient, administered intravenously 40% dextrose (glucose);intramuscularly, subcutaneously, – glucagon (0.5-1 mg).After regaining consciousness of the patient is recommended to take food rich in carbohydrates, to prevent recurrence of hypoglycemia.Interactions with other medicinal products
There are a number of drugs that affect the need for insulin, hypoglycemic action of insulin increase the oral hypoglycemic drugs, monoamine oxidase inhibitors, angiotensin-converting enzyme, carbonic anhydrase inhibitors, non-selective beta-blockers, bromocriptine, sulphonamides, anabolic steroids, tetracyclines, clofibrate ketoconazole, mebendazole. pyridoxine theophylline, cyclophosphamide, fenfluramine, lithium, drugs containing ethanol. Hypoglycemic effect of insulin impaired oral contraceptives, steroids, thyroid hormones, thiazide diuretics, heparin, tricyclic antidepressants, sympathomimetics, danazol, clonidine, calcium channel blockers, diazoxide, morphine, phenytoin, nicotine.
Under the influence of reserpine and salicylates may both weakening and strengthening of the drug.
Beta-blockers may mask the symptoms of hypoglycaemia and hamper the elimination of hypoglycaemia.
Octreotide / lanreotide may both decrease and increase insulin requirement.
Alcohol may intensify and prolong the hypoglycaemic effect of insulin. Incompatibility in general, insulin can be used only with those compounds, omnadren with which he is known to be compatible. The suspensions of insulin can not be added to infusion solutions.
When properly selected dose or treatment withdrawal may develop hyperglycemia , especially in patients with type 1 diabetes. First symptoms usually manifested hyperglycemia gradually over several hours or days. These symptoms include nausea, vomiting, severe drowsiness, flushed dry skin, dry mouth, increased urine output, thirst, loss of appetite as well as acetone odor from the mouth.
If you do not treat hyperglycemia in diabetes mellitus type 1 can lead to life-threatening diabetic ketoacidosis. In cases of significant improvement in glycemic control, eg by intensified insulin therapy, may also change the usual symptoms of hypoglycemia-harbingers of what patients should be warned.
If concomitant diseases, especially in infections and feverish conditions, patients need insulin usually increases. If the patient is transferred from one to another type of insulin, the earliest precursors simptomy- hypoglycemia may change or become less pronounced than those observed when administered prior insulin.
The transfer of patients to different type of insulin or other insulin kompanii- manufacturer should only under medical supervision. If you change omnadren the biological activity, the change of the manufacturer, type, species (animal, human, human insulin analog) and / or method of manufacture may need to modify the dosing regimen.
If you need a dose adjustment, it can be done even at first dose or during the first week or months of therapy.
Skipping a meal or unplanned heavy exercise can cause hypoglycemia.
If the patient will travel crossing time zones, it should consult with your doctor, because he would have to change the administration of insulin and food intake.
The preparation omnadren include m-cresol, which may cause allergic reactions.
- Effects on ability to drive and use machines The ability of patients to focus concentration and reaction speed can be violated at the time of hypoglycemia and hyperglycemia, which may pose a risk to situations where these capabilities are especially needed (for example, while driving or operating; machines and mechanisms). Patients should be advised to take measures to prevent hypoglycemia and hyperglycemia when driving and operating machinery. This is especially important for patients with absence or reduction in the severity of symptoms-precursors of developing hypoglycemia or suffering from frequent episodes of hypoglycaemia. In these cases, you should consider the advisability of driving.